Researchers with the Los Alamos National Laboratory wrote “Hollow fiber integrated microfluidic platforms for in vitro Co-culture of multiple cell types” in the October 2016 issue of Biomedical Microdevices. The scientists inserted our 0.2 µm ME hollow fibers into silicone tubing to create bioreactors.

The scientists are advancing the tissue regeneration processes through the creation of hollow fiber integrated devices. “The integration of HFs into microfluidic devices can introduce additional features such as higher surface-to-volume ratio for increased mass transfer and tubular environments to mimic the shape of several in vivo organs.” The researchers demonstrated the successes of using these hollow fiber integrated systems and theorize more complex applications for the technology.

Abstract: This study demonstrates a rapid prototyping approach for fabricating and integrating porous hollow fibers (HFs) into microfluidic device. Integration of HF can enhance mass transfer and recapitulate tubular shapes for tissue-engineered environments. We demonstrate the integration of single or multiple HFs, which can give the users the flexibility to control the total surface area for tissue development. Click here to read the article.

 

Mixed Cellulose Ester (ME) is a hydrophilic membrane filtration chemistry that provides higher flux rates for faster processing times and low protein binding for higher product yields. ME filter chemistry is also highly biocompatible making it useful for filtration applications with cells and cell and virus lysates.

doi: 10.1007/s10544-016-0102-y