Researchers with the Georgia Institute of Technology and Emory University wrote “Gelatin methacrylate microspheres for controlled growth factor release” in the February 2015 issue of Acta Biomaterialia. The scientists studied gelatin microparticles due to their use in diverse applications. Our 12-14 kDa Spectra/Por dialysis tubing was used to produce gelatin methacrylate (GMA) from gelatin.

This study is the first to characterize the physical properties of GMA as well as growth factor binding and release. The researchers demonstrated that the “modulation of microparticles (MP) cross-linking density via gelatin methacrylation facilitates greater control over critical MP properties compared to conventional glutaraldehyde cross-linked MPs, and this enhanced control enables the tailoring of particles for a variety of tissue engineering purposes.” The produced GMA MPs provide a strong platform in the developing tissue engineering technologies.

Abstract: Gelatin has been commonly used as a delivery vehicle for various biomolecules for tissue engineering and regenerative medicine applications due to its simple fabrication methods, inherent electrostatic binding properties, and proteolytic degradability. Compared to traditional chemical cross-linking methods, such as the use of glutaraldehyde (GA), methacrylate modification of gelatin offers an alternative method to better control the extent of hydrogel cross-linking. Here we examined the physical properties and growth factor delivery of gelatin methacrylate (GMA) microparticles formulated with a wide range of different cross-linking densities. Click here to read the full article.

 

Standard Grade Regenerated Cellulose (RC) is a clear, flexible and sturdy dialysis membrane with a “looser” molecular selectivity. This economical membrane is ideal for a broad range of applications in which there is a significant size difference between the MW species being separated.