Researchers with the Koch Institute for Integrative Cancer Research published “Highly Scalable, Closed-Loop Synthesis of Drug-Loaded, Layer-by-Layer Nanoparticles” in the January 2016 issue of Advanced Functional Materials. The scientists used our KrosFlo® Research IIi TFF System and either a 100 kDa or 500 kDa mPES MidiKros®, depending on the size of the colloid substrates.
Abstract: Layer-by-layer (LbL) self-assembly is a versatile technique from which multicomponent and stimuli-responsive nanoscale drug-carriers can be constructed…. In this report, a generalizable method for increasing throughput with LbL assembly is described by using highly scalable, closed-loop diafiltration to manage intermediate purification steps. Click here to read the report.
Modified Polyethersulfone (mPES) is an advanced hydrophilic membrane filtration chemistry that provides higher flux rates for faster processing times, excellent selectivity for separation applications, and low protein binding for higher product yields than other membrane chemistries. Spectrum’s new modified Polyethersulfone hollow fiber filters provide all the benefits of modified PES chemistry in fully encapsulated filter modules that are priced for Single-Use. Click here for more information on mPES.