In June 2016, scientists with University College London published “Purification of Nanoparticles by Size and Shape” in Scientific Reports. The researchers used the KrosFlo® Research IIi System (KRIIi) and 50 nm hollow fiber modules.

Abstract: Size and shape are important parameters for nanoparticle-based drug delivery, that control the kinetics of internalisation, biodistribution, cellular membrane deformability, and cargo loading efficiency. It has been shown that smaller nanoparticles escape natural body clearance mechanisms more efficiently and, hence, circulate longer in the blood. Click here to read the full article.

The scientists highlight the benefits of Cross Flow Filtration–also known as Tangential Flow Filtration (TFF)–for their process. TFF is favorable because the material running through the filter does not stick to the membrane surface, as it can in dead-end filtration. Another asset to TFF is the high and consistent flow rate that allows the technician to collect both the permeate (the particulate going through the membrane) and the retentate (the material running through the module).

 

SpectrumLabs.com offers a TFF training program with Jim Simmons, a 30-year veteran of membrane separations. He is also writing a series of posts on the Fundamentals of TFF for this blog.

We recently launched the second generation KR2i! Read more here.

doi: 10.1038/srep27494