Scientists with the Center for Pharmaceutical Biotechnology and Nanomedicine at Northeastern University published a paper in the August 2016 issue of the European Journal of Pharmaceutics and Biopharmaceutics. In this paper, titled “Anti-cancer activity of doxorubicin-loaded liposomes co-modified with transferrin and folic acid”, the researchers used SpectrumLabs 300 kDa Biotech CE pre-wetted dialysis tubing and 12-14 kDa Spectra/Por® 4 Standard RC dry dialysis tubing.

The researchers used our 300 kDa membrane to remove folic acid and the 12-14 kDa membrane “to exchange the outer liposomal buffer”. The scientists found that the processed liposomes were able to inhibit tumor growth.

Abstract: Cancer-specific drug delivery represents an attractive approach to prevent undesirable side-effects and increase the accumulation of the drug in the tumor. Surface modification of nanoparticles such as liposomes with targeting moieties specific to the up-regulated receptors on the surface of tumor cells thus represents an effective strategy. Click here to read the paper.

 

Standard Grade Regenerated Cellulose (RC) is a clear, flexible and sturdy dialysis membrane with a “looser” molecular selectivity. This economical membrane is ideal for a broad range of applications in which there is a significant size difference between the MW species being separated. Click here for more information about RC membranes.

doi: 10.1016/j.ejpb.2016.05.023