In the April 2014 issue of the  International Journal of Pharmaceutics, researchers at the University of Connecticut School of Pharmacy published a paper titled “Formulation parameters of crystalline nanosuspensions on spray drying processing: A DoE approach”. These scientists developed a “dialysis sac adapter for USP apparatus II” using our Float-A-Lyzer® G2 dialysis device with a 1000 kDa molecular weight cutoff (MWCO). The adapter as described in the paper could be used for other liquid formulations and may prove useful to the pharmaceutical industry.

 

Abstract: Nanocrystalline suspensions offer a promising approach to improve dissolution of BCS class II/IV compounds. Spray drying was utilized as a downstream process to improve the physical and chemical stability of dried nanocrystals. The effect of nanocrystalline suspension formulation variables on spray-drying processing was investigated. Click here to read more.

The Float-A-Lyzer® G2 dialysis device is packaged dry and easy to use with all components included.

Spectrum’s proprietary Biotech Grade CE is a low protein-binding synthetic membrane available in 9 precise MWCO’s with no heavy metal and sulfide contaminants. Only the Float-A-Lyzer G2 assures a greater than 90% sample recovery while maintaining greater than 95% sample purity and minimal sample dilution.

Click here for more information about the Float-A-Lyzer® G2.

 doi: 10.1016/j.ijpharm.2014.01.013