In January 2017, scientists from the Department of Engineering at Temple University used Spectrum Labs’ MicroKros® in “Targeted multidrug delivery system to overcome chemoresistance in breast cancer”, published in the International Journal of Nanomedicine. The scientists used the MicroKros to prepare liposomes.

The researchers looked for a solution to minimize side effects and nullify drug resistance in breast cancer treatments. Their proposal was to encapsulate “anticancer compounds into drug carriers to achieve targeted delivery”. The subsequent studies indicate that the targeted treatments attack tumor growth and this therapy has potential for patients with breast cancer.

Abstract: Chemotherapy has been widely used in breast cancer patients to reduce tumor size. However, most anticancer agents cannot differentiate between cancerous and normal cells, resulting in severe systemic toxicity…. With the proper treatment strategy, nanodrug carriers, such as liposomes/immunoliposomes, may be able to reduce undesired side effects of chemotherapy, to overcome the acquired multidrug resistance, and to further improve the treatment efficacy. Click here to read the article.

 

MicroKros Filter Modules are designed for tangential flow filtration of small volumes ranging from 1 mL to 100 mL. Single-use MicroKros hollow fiber filters are the first efficient and practical tangential flow filtration device for characterizing a process for scale-up or filtration of small volumes in a laboratory setting.

doi: 10.2147/IJN.S124770