Scientists with the University of Rochester wrote “Development of Poly(Ethylene Glycol) Hydrogels for Salivary Gland Tissue Engineering Applications” in the April 2015 issue of Tissue Engineering: Part A. The researchers dialyzed peptides with Spectrum Labs’ dialysis tubing. The peptides were used to analyze cell function.

The scientists looked for a reproducible process to promote cell “regeneration and functional recovery
of irradiated salivary glands” for restored gland function after cancer. They proposed polyethylene glycol (PEG) hydrogels for the submandibular gland (SMG) cell transplantation.

Abstract: More than 40,000 patients are diagnosed with head and neck cancers annually in the United States with the vast majority receiving radiation therapy. Salivary glands are irreparably damaged by radiation therapy resulting in xerostomia, which severely affects patient quality of life. Cell-based therapies have shown some promise in mouse models of radiation-induced xerostomia, but they suffer from insufficient and inconsistent gland regeneration and accompanying secretory function. To aid in the development of regenerative therapies, poly(ethylene glycol) hydrogels were investigated for the encapsulation of primary submandibular gland (SMG) cells for tissue engineering applications. Click here to read the article.

 

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doi: 10.1089/ten.tea.2014.0674