Researchers from the University of Helsinki in Finland wrote “Hyaluronic Acid Graft Copolymers with Cleavable Arms as Potential Intravitreal Drug Delivery Vehicles” for the January 2018 issue of Macromolecular Bioscience. In the paper, the scientists used Spectra/Por® dialysis tubing to study the stabilization of hyaluronic acid (HA) during release experiments.
The researchers studied proposed sustained drug release release systems for ocular degeneration treatments using HA grafted to a water-soluable delivery vehicle. In the paper, they found little to no degradation of the HA sample when using the 25 kDa dialysis tubing to remove buffer salts.
Abstract: Treatment of retinal diseases currently demands frequent intravitreal injections due to rapid clearance of the therapeutics. The use of high molecular weight polymers can extend the residence time in the vitreous and prolong the injection intervals. This study reports a water soluble graft copolymer as a potential vehicle for sustained intravitreal drug delivery. The copolymer features a high molecular weight hyaluronic acid (HA) backbone and poly(glyceryl glycerol) (PGG) side chains attached via hydrolysable ester linkers. Click here to read the article.
Large-volume Process Dialysis is an emerging technology driven by the increasing demand for gentle and consistent multi-batch purification at the production scale. Process Dialysis facilitates dynamic buffer flow around the membrane-encased sample to increase purification efficiency and improve large buffer handling for the production of fragile proteins, viscous fluids and polymer gels, such as hyaluronic acid.