Scientists from the Royal College of Surgeons in Ireland wrote “Incorporation of fibrin into a collagen–glycosaminoglycan matrix results in a scaffold with improved mechanical properties and enhanced capacity to resist cell-mediated contraction” for the October 2015 issue of Acta Biomaterialia. In the article, the researchers used Spectra/Por dialysis tubing to incorporate fibrin into their solution.

Abstract: Fibrin has many uses as a tissue engineering scaffold, however many in vivo studies have shown a reduction in function resulting from the susceptibility of fibrin to cell-mediated contraction. The overall aim of the present study was to develop and characterise a reinforced natural scaffold using fibrin, collagen and glycosaminoglycan (FCG), and to examine the cell-mediated contraction of this scaffold in comparison to fibrin gels. Through the use of an injection loading technique, a homogenous FCG scaffold was developed. Click here to read the article.

 

Standard Grade Regenerated Cellulose (RC) is a clear, flexible and sturdy dialysis membrane with a “looser” molecular selectivity. This economical membrane is ideal for a broad range of applications in which there is a significant size difference between the MW species being separated; including sample prep, desalting, buffer exchange, pH change, and protein purification.

doi: 10.1016/j.actbio.2015.08.022