The Vaccines Research department of Novartis Vaccines published “Fabrication of cell culture-derived influenza vaccine dissolvable microstructures and evaluation of immunogenicity in guinea pigs” in the June 2015 issue of Vaccine. This paper discusses the use of our mPES filter modules and the KrosFlo® Tangential Flow Systems to concentrate influenza monobulks.

The researchers at Novartis looked into alternative methods of delivery for the influenza vaccine in skin patches. “Alternative patch architectures for skin delivery include coated solid microstructures, solid hollow microstructures, and drug encapsulated in dissolvable microstructures.” Patch delivery for vaccines could simplify the circulation of the seasonal flu vaccine as well as ease the distribution of vaccines during pandemics.

Abstract: Microstructure patches provide an opportunity for simple, effective, and safe vaccine administration, while achieving the desired immune response…. Influenza monovalent purified bulk vaccines (monobulks) (H1N1, H3N2, B) were concentrated by tangential flow filtration, lyophilized, and formulated with biocompatible excipients to form the microstructure array dissolvable tips. Click here to read the article.


The KMPi TFF System [KroFlo MiniKros Pilot Tangential Flow Filtration (TFF) System] is the ideal system for precise and reproducible control and documentation of Tangential Flow Filtration processes ranging from 10 to 1000 Liters. The KMPi is a part of our scalable line of TFF systems, compatible with MiniKros® Samplers, MiniKros, and KrosFlo filter modules.