Researchers with The University of Texas MD Anderson Cancer Center (MDACC) wrote “Metronomic Docetaxel in PRINT Nanoparticles and EZH2 Silencing Have Synergistic Antitumor Effect in Ovarian Cancer” for the July 2014 issue of Molecular Cancer Therapeutics. In the paper, the scientists used Spectrum Labs’ hollow fiber tangential flow filters to purify and concentrate nanoparticles containing docetaxel.

In cancer care, there is an urgent need to develop technologies and therapies “with improved drug efficacy and reduced toxicity”.The scientists discovered a pronounced antitumor effect from tge nanoparticle containing docetaxel therapy.

Abstract: The purpose of this study was to investigate the antitumor effects of a combination of metronomic doses of a novel delivery vehicle, PLGA-PRINT nanoparticles containing docetaxel, and antiangiogenic mEZH2 siRNA incorporated into chitosan nanoparticles. In vivo dose-finding studies and therapeutic experiments were conducted in well-established orthotopic mouse models of epithelial ovarian cancer. Antitumor effects were determined on the basis of reduction in mean tumor weight and number of metastatic tumor nodules in the animals. Click here to read the full article.

 

Modified Polyethersulfone (mPES) is an advanced hydrophilic membrane filtration chemistry that provides higher flux rates for faster processing times, excellent selectivity for separation applications, and low protein binding for higher product yields than other membrane chemistries.

doi 10.1158/1535-7163.MCT-13-0930