Scientists from Harvard University wrote “Injectable nanocomposite cryogels for versatile protein drug delivery” for the January 2018 issue of Acta Biomaterialia. In the paper, the researchers used the KR2i in their cryogel synthesis “for simple and versatile controlled release of therapeutic proteins”.

In this study, the Harvard scientists created cryogels formulated with covalently crosslinked hydrogels and Laponite nanoparticles to improve protein delivery capabilities. They developed an  “injectable, macroporous hydrogel system” that is simple to construct, and addresses the flaws of current hydrogel drug delivery systems.

Abstract: Sustained, localized protein delivery can enhance the safety and activity of protein drugs in diverse disease settings. While hydrogel systems are widely studied as vehicles for protein delivery, they often suffer from rapid release of encapsulated cargo, leading to a narrow duration of therapy, and protein cargo can be denatured by incompatibility with the hydrogel crosslinking chemistry. In this work, we describe injectable nanocomposite hydrogels that are capable of sustained, bioactive, release of a variety of encapsulated proteins. Click here to read the article.

 

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doi: 10.1016/j.actbio.2017.11.024